Bouncing universe models in an extended gravity theory

Some bouncing models are investigated in the framework of an extended theory of gravity. The extended gravity model is a simple extension of the General Relativity where an additional matter geometry coupling is introduced to account for the late time cosmic speed up phenomena. The dynamics of the models are discussed in the background of a flat FRW universe. Some viable models are reconstructed for specifically assumed bouncing scale factors. The behavior of the models are found to be decided mostly by the parameters of the respective models. The extended gravity based minimal matter-geometry coupling parameter has a role to remove the omega singularity occurring at the bouncing epoch. It is noted that the constructed models violate the energy conditions, however, in some cases this violation leads to the evolution of the models in phantom phase. The stability of the models are analyzed under linear homogeneous perturbations and it is found that, near the bounce, the models show instability but the perturbations decay out smoothly to provide stable models at late times.     

“Quad-band flexible magnesium zinc ferrite (MgZnFe2O4)-based double negative metamaterial for microwave applications”

This article presents vertically coupled, rectangular complementary split-ring resonator-shaped quad-band double-negative (DNG) metamaterial unit cells, that is, having both negative permittivity and permeability, which redirect negative refractive and also are not found in nature. The metamaterial is fabricated on magnesium zinc ferrite-based flexible microwave substrates, and the flexible substrates are chosen with two different concentrations of magnesium (Mg) denoted by Mg₃₀ and Mg₅₀ for 30% and 50% of Mg, which possess dielectric constants of 4.32 and 3.15 and loss tangents of 0.003 and 0.005, respectively. The proposed metamaterials are demonstrated by utilizing the CST microwave simulator, and their effective parameters are extracted according to the Nicolson-Ross-Wire method. With Mg_30, the prepared, flexible metamaterial shows measured resonances at 3.70 GHz, 7 GHz, 8.60 GHz, and 9.78 GHz, whereas with Mg₅₀ it shows the measured resonances at 4.10 GHz, 7.70 GHz, 9.33 GHz, and 10.62 GHz. Very good effective medium ratios (EMR) along with DNG properties are obtained, namely 6.5 and 5.85 for Mg₃₀ and Mg_50, respectively, with a physical dimension of 12.5 × 9.5 mm² for both of the unit cells_. Also, the electric field, magnetic field, and surface current distribution at different resonances and the polarization insensitivity at different polarization angles were observed. Thus, the designed new flexible substrate microwave materials based on DNG metamaterials are potential candidates for S-, C- and X-band applications, as well as for flexible microwave technologies.     

Structures and energetics of darunavir and active site amino acids of native and mutant HIV–1 protease: a computational study

Structural Chemistry - Quantum chemical calculations have been performed at the M06–2X/6–31G(d,p) level of theory to investigate the strength and nature of interactions between the...     

Synergic Synthesis and Characterization of tert-Butyl 4-[(E)-But-1-en-3-yn-1-yl]-3-{[tert-butyl(dimethyl)silyl]oxy}-1H-indole-1-carboxylate

Russian Journal of Organic Chemistry - tert-Butyl 4-[(E)-but-1-en-3-yn-1-yl]-3-{[tert-butyl(dimethyl)silyl]oxy}-1H-indole-1-carboxylate has been synthesized with a good yield and selectivity...     

Easy and Efficient Microwave-Assisted Synthesis of 1,2,3-Triazolyl-Tethered 2-Pyridinylbenzimidiazoles and Their Antimicrobial Activity

Russian Journal of Organic Chemistry - A series of novel 1,2,3-triazole-tethered 2-pyridinylbenzimidazole derivatives have been synthesized form 2-(pyridine-3-yl)benzimidazole under microwave...     

Synthesis,computational quantum chemical study,in silico ADMET and molecular docking analysis,in vitro biological evaluation of a novel sulfur heterocyclic thiophene derivative containing 1,2,3-triazole and pyridine moieties as a potential human topoisomerase IIα inhibiting anticancer agent

Computational quantum chemical study and biological evaluation of a synthesized novel sulfur heterocyclic thiophene derivative containing 1,2,3-triazole and pyridine moieties namely BTPT [2-(1-benzyl-5-methyl-1H-1,2,3-triazol-4-yl)-6-methoxy-4-(thiophen-2-yl) pyridine] was presented in this study. The crystal structure was determined by SCXRD method. For the title compound BTPT, spectroscopic characterization like ¹H NMR, ¹³C NMR, FTIR, UV–vis were carried out theoretically by computational DFT method and compared with experimental data. Druglikeness parameters of BTPT were found through in silico pharmacological ADMET properties estimation. The molecular docking investigation was performed with human topoisomerase IIα (PDB ID:1ZXM) targeting ATP binding site. In vitro cytotoxicity activity of BTPT/doxorubicin were examined by MTT assay procedure against three human cancer cell lines A549, PC-3, MDAMB-231 with IC50 values of 0.68/0.70, 1.03/0.77 and 0.88/0.98 μM, respectively. Our title compound BTPT reveals notable cytotoxicity against breast cancer cell (MDAMB-231), moderate activity with human lung cancer cell (A-549) and less inhibition with human prostate cancer cell (PC-3) compared to familiar cancer medicine doxorubicin. From the results, BTPT could be observed as a potential candidate for novel anticancer drug development process.     

Novel Etodolac-Based 1,2,4-Triazole Derivatives as Antimicrobial Agents: Synthesis,Biological Evaluation,and Molecular Docking Study

Russian Journal of Organic Chemistry - A series of novel 1,2,4-triazole nonsteroidal anti-inflammatory drugs (NSAIDs) derived from etodolac were designed and synthesized. The synthesized compounds...